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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTB

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 522-526 doi: 10.1007/s11684-016-0485-4

Abstract: Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permissionAutologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, andAfter the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient&rsquo

Keywords： autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cellsCurrent NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potentiallines and genetically modifying fresh NK cells or NK cell lines.chimeric tumor antigen receptors could improve their specificity and cytotoxicity.In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: therapies or procedures instead of autologous/allogeneic bone grafts.Regenerative medicine, based on stem cell science and tissue engineering technology, is considered asan ideal alternative strategy for bone regeneration.In this paper, we review the current choices of cell source and strategies on directing the osteogenicWe propose comprehensive strategies based on stem cell and tissue engineering researches, allowing for

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

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Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 160-188 doi: 10.1007/s11684-018-0629-9

Abstract: Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defectsto address the unmet need for bone augmentation and skeletal repair.Effective therapies for bone regeneration primarily require the coordinated combination of innovativeHowever, current techniques in bone tissue engineering have not yet reached valid translation into clinicalWe describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions

Keywords： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionof CAR-T cell therapy.

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

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A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 711-725 doi: 10.1007/s11684-020-0808-3

Abstract: Based on recent clinical data, approximately 50% of patients with relapsed or refractory B-cell lymphomaachieved complete remission after receiving the CD19 CAR-T cell therapy.Therefore, optimizing the structure of CAR, creating new drugs, and combining CAR-T cell therapy withstem cell transplantation are potential solutions to increase the effectiveness of treatment and reducethe toxicity in patients with lymphoma after the CAR-T cell therapy.

Keywords： chimeric antigen receptor T (CAR-T) cell     lymphoma     cytokine release syndrome (CRS)     immune effector cell-associated    

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Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Keywords： tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

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Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract: Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistancetargeting CSC populations that is becoming increasingly important for eradicating CSCs in heterogeneous tumor

Keywords： cancer stem cell     tumor model     drug discovery    

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: chemical interference approaches revealed that the loss of GNAQ/11 palmitoylation substantially affected tumorcell proliferation and survival in UM cells.Importantly, the palmitoylation-deficient oncogenic GNAQ/11 failed to rescue the cell death initiatedoncogenes in UM cells, which are much more dependent on Gαq/11 signaling for cell

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: This paper aims to evaluate the effects and the possible mechanisms of atorvastatin on tumor growth andmetastasis in a xenograft tumor model.Atorvastatin suppressed xenograft tumor growth and metastasis both in the low-dose and the high-doseHowever, atorvastatin did not alter the expression of CYP2J2 in tumor tissue.This suggests that atorvastatin has the efficacy of suppressing tumor growth and metastasis .

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: investigate the extracellular regulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cell(GMC) proliferation and tumor necrosis factor-α (TNF-α) expression.HBx upregulates TNF-α expression and induces cell proliferation of GMC line partly through ERK signal

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract:

Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developingmore effective therapies that target highly tumorigenic and drug-resistant cancer stem cell (CSC) populationsIn this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched into tumorspheroids under stem cell conditions from a non-small cell lung cancer cell line.underlying the drug resistance of CSCs and for guiding the development of better therapies that can inhibit tumor

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Advances in Autologous Bone Marrow Stem Cell Transplantation

Li Lianda,Wu Limao,Liu Hong,Ning Keyong,Li Yikui

Strategic Study of CAE 2004, Volume 6, Issue 8,   Pages 1-4

Abstract: It can augment cell number in diseased organs, and has shown early promising.However cell therapy is partially hindered by immunological rejection, cellular source, and medical ethicsBone marrow cells can be easily obtained from adult marrow, opening the possibility of autologous transplantationIt also discusses the current status of autologous bone marrow stem cell transplantation with emphaseson approaches to stem cell mobilization.

Keywords： bone marrow stem cells     autologous transplantation     bone marrow mobilizer    

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The Formation of the Concept “Open Complex Giant System”

Lu Mingsen

Strategic Study of CAE 2004, Volume 6, Issue 5,   Pages 17-23

Abstract:

On the basis of the analysis of the formation background of the concept “open complex giantletters published by Academician Qian Xuesen, this paper studies emphatically the abstract process of giantsystem → complex giant system → open complex giant system， introduces briefly the basic contentof the theory of open complex giant system, and expounds that the formation of this theory has significance

Keywords： giant system     complex giant system     open complex giant system     Meta-synthesis     system science     noetic science    

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Title Author Date Type Operation

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Journal Article

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Journal Article

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Advances in Autologous Bone Marrow Stem Cell Transplantation

Li Lianda,Wu Limao,Liu Hong,Ning Keyong,Li Yikui

Journal Article

The Formation of the Concept “Open Complex Giant System”

Lu Mingsen

Journal Article